2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131579R
    Deschloro Cetirizine (dihydrochloride) (Standard)
    Pyrocatechuic acid (Standard) is the analytical standard of Pyrocatechuic acid. This product is intended for research and analytical applications. Pyrocatechuic acid is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion.
    Deschloro Cetirizine (dihydrochloride) (Standard)
  • HY-G0023R
    Niraparib metabolite M1 (Standard)
    Berberine (hemisulfate) (Standard) is the analytical standard of Berberine (hemisulfate). This product is intended for research and analytical applications. Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity.
    Niraparib metabolite M1 (Standard)
  • HY-100655R
    O-Desmethyl apixaban (Standard)
    O-Desmethyl apixaban (Standard) is the analytical standard of O-Desmethyl apixaban. This product is intended for research and analytical applications. O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01). Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively.
    O-Desmethyl apixaban (Standard)
  • HY-G0021R
    N-Desmethylclozapine (Standard)
    N-Desmethylclozapine (Standard) is the analytical standard of N-Desmethylclozapine. This product is intended for research and analytical applications. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist.
    N-Desmethylclozapine (Standard)
  • HY-148846
    Mosapride N-Oxide
    Mosapride N-Oxide is a major active metabolite of Mosapride. Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
    Mosapride N-Oxide
  • HY-133797
    Cyclobenzaprine N-oxide
    Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine (HY-B0740) in liver particles. Cyclobenzaprine is a skeletal muscle relaxant and is active on the central nervous system. The liver cytosol from liver particles has reductase activity that can reduce Cyclobenzaprine N-oxide to the corresponding amine.
    Cyclobenzaprine N-oxide
  • HY-W021399S
    Lidocaine impurity 5-d6
    Lidocaine impurity 5-d6 is deuterium labeled Lidocaine impurity 5.
    Lidocaine impurity 5-d<sub>6</sub>
  • HY-143987S
    DM51 impurity 1-d9
    DM51 impurity 1-d9 is the deuterium labeled DM51 impurity 1[1].
    DM51 impurity 1-d<sub>9</sub>
  • HY-147336
    Desmethylazelastine
    Desmethylazelastine is a main active metabolite of Azelastine that is oxidatively metabolized by the cytochrome P450 enzyme system with a protein binding rate of 97% and an elimination half-life of 54 hours. Azelastine is an orally active, selective and high-affinity histamine H1-receptor antagonist. Azelastine can be used in studies of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.
    Desmethylazelastine
  • HY-G0025
    Tetrabenazine Metabolite
    Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM). Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders.
    Tetrabenazine Metabolite
  • HY-P3147
    IYPTNGYTR
    IYPTNGYTR, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR can be used to monitor in vivo Trastuzumab metabolism.
    IYPTNGYTR
  • HY-118167
    Monoethylglycinexylidide
    Monoethylglycinexylidide is a metabolite of Lidocain (HY-B0185) via oxidative N-deethylation of Lignocaine by liver cytochrome P-450 enzymes in the liver[1].
    Monoethylglycinexylidide
  • HY-12771S
    O-Desmethyl Mebeverine acid-d5
    		98.45%
    O-Desmethyl Mebeverine acid-d5 is the deuterium labeled O-desmethyl Mebeverine acid.
    O-Desmethyl Mebeverine acid-d<sub>5</sub>
  • HY-100057
    BMY 28674
    BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 μM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 μM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.
    BMY 28674
  • HY-143954S
    Epinephrine impurity 19-d3 hydrochloride
    Epinephrine impurity 19-d3 (hydrochloride) is the deuterium labeled Epinephrine impurity 19[1].
    Epinephrine impurity 19-d<sub>3</sub> hydrochloride
  • HY-113474R
    3,4-Dihydroxymandelic acid (Standard)
    3,4-Dihydroxymandelic acid (Standard) is the analytical standard of 3,4-Dihydroxymandelic acid. This product is intended for research and analytical applications. 3,4-Dihydroxymandelic acid is a metabolite of norepinephrine.
    3,4-Dihydroxymandelic acid (Standard)
  • HY-150092
    8(S),9(R)-EET
    8(S),9(R)-EET is an eicosanoid product of Arachidonic acid (AA; HY-109590) by cytochromes P450. 8(S),9(R)-EET dilates canine epicardial arterioles in a concentration-dependent manner with an EC50 value of 121 nM.
    8(S),9(R)-EET
  • HY-B0199R
    Mycophenolate Mofetil (Standard)
    Mycophenolate Mofetil (Standard) is the analytical standard of Mycophenolate Mofetil. This product is intended for research and analytical applications. Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation.
    Mycophenolate Mofetil (Standard)
  • HY-126857S3
    5-Hydroxyomeprazole-d3-1
    5-Hydroxyomeprazole-d3-1 is the deuterium labeled 5-Hydroxyomeprazole[1].
    5-Hydroxyomeprazole-d<sub>3</sub>-1
  • HY-135410
    ABZ-amine
    ABZ-amine (Amino albendazole) is an impurity of Albendazole. Albendazole is a member of the benzimidazole compounds used as a agent indicated for the treatment of a variety of worm infestations.
    ABZ-amine
Cat. No. Product Name / Synonyms Application Reactivity